Our results showed that adult IRSp53 re-expression rescues social interaction but not hyperactivity or anxiety-like behavior in IRSp53-cKO mice, reminiscent of social but not hyperactivity rescue in IRSp53-global KO mice treated with memantine (NMDAR antagonist) and MPEP (mGluR5 antagonist)29. The gene discussed is GRM5; the disease is Anxiety.