Of which, Liu et al.35 analyzed the difference between ErbB pathway mutation and non-mutation group within 13 patients with gallbladder cancer, and found that in the mutation group, the higher levels of midkine (MDK) secreted by epithelial cells interacted with its receptor LRP1 expressed by macrophages to promote immunosuppressive microenvironment. Here, LRP1 is linked to gallbladder cancer.