Fatty liver is associated with obesity, insulin resistance and diabetes may cause chronic inflammation, adipose tissue remodeling, increased circulating level of pro-inflammatory cytokine (C-reactive protein, interleukin-6, monocyte chemotactic protein 1, and TNF-a)1,13, which is also metabolic syndrome pathogenesis. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.