Overall, the association of underexpression of STUB1 in an inflamed tumour microenvironment (GEPhi) and the overexpression of STUB1 in immunologically “cold” tumours (prostate and breast) support our interpretation of STUB1 as an immunosuppressive gene, which likely constrains IFNγ sensing in the cancer-immunity cycle47. This evidence concerns the gene IFNG and neoplasm.