In this study, three common genes, including GJB2, SLC26A4, MT-RNR1, accounted for 85.54% (503/588, 35.20%, 47.28%, 3.23%, respectively) of the diagnostic patient group, while 32 uncommon HL-related genes accounted for the remaining 14.46% (85/588) of the diagnostic yield. Here, GJB2 is linked to Hodgkins lymphoma.