While it has been reported in 459 HL patients from the United States, 28% (128) had positive genetic testing, with the leading five involved genes as GJB2, TMPRSS3, SLC26A4, MYO7A, and MT-RNR1 (16%, 10%, 8%, 7%, 5%, respectively) [34]. Here, TMPRSS3 is linked to Hodgkins lymphoma.