An acute dose of L-DOPA (6 mg/kg) was sufficient to rescue ambulation, vertical counts, and pole assay deficits (Fig. 2l, m), without having any effect on wildtype mice, confirming that deletion of Esrrg selectively from DAergic neurons is sufficient to cause a L-DOPA-responsive, PD-like phenotype. Here, ESRRG is linked to Parkinson disease.