ESRRG and Parkinson disease: Subsequently, we prioritized genes for in vivo validation using several criteria: downregulation of the gene in BAC-TRAP data (more likely than upregulated genes to be direct targets of ERRγ transcriptional activation programs), demonstration of regulation by ERRγ overexpression in the catecholaminergic SH-SY5Y cell line, overlap with genes implicated by PD GWAS and QTL studies, and expression in DAergic neurons of the mouse brain (Supplementary Fig. 7c; Dropviz.org30).