Among them, two CpGs (cg03546163 and cg14195992), mapped to the FKBP5 and SPIDR genes, also reached genome-wide significance in another large meta-analysis of multiple EWAS (of Amyotrophic lateral sclerosis, Parkinson’s disease, and AD)16, suggesting these two CpGs corresponded to susceptibility loci common in neurodegenerative diseases. The gene discussed is FKBP5; the disease is amyotrophic lateral sclerosis.