To analyse if modulation of FMR1 expression could affect tumor growth in vivo we used xenografts of GSCs in which we reduced FMRP expression using lentiviral vectors expressing either shRNA against the FMR1 mRNA (shFMR1) or a non-target control (shNTC) in three GSC lines that are characterized by high FMRP expression and poor prognosis (#148, #163 and #169; Fig. 1C and Supplementary Table 1). The gene discussed is FMR1; the disease is neoplasm.