Importantly, the Ang II-induced response was remarkably reversed in the retinas of CXCR2 KO mice (Figs. S2B–C), suggesting that CXCR2 KO not only attenuates the proinflammatory response but also alleviates vascular leakage and BRB breakdown, which protects against Ang II-induced retinopathy in mice. This evidence concerns the gene AGT and retinal disorder.