TP53 and neurodegenerative disease: Although the whole landscape of P53 isoform network in human physiology, cancer, and degenerative diseases remains largely unknown, accumulated evidence based on clinical studies as well as studies with cell lines and animal models supports the notion that depending on the cellular or tissue context, P53 isoforms are differentially co‐expressed and work in concert to define cellular responses, suggesting the complication in deciphering the consequence of any alterations at the TP53 locus [3].