IL10 and uveitis: This study supports that a single dose of AAV-mediated gene transfer of cDNA encoding an immunosuppressive cytokine, IL-10, may reduce or eliminate the need for uveitis treatment such as topical corticosteroids, systemic anti-inflammatories, and/or surgical interventions, and thus mitigate the risks of local or systemic immune suppression, while still reducing ocular inflammation and preserving long-term vision.