In each of these models, PDAC xenograft volume and weight were greater in microbiota-intact mice (SPF-Rag1−/−, Ex-GF-Rag1−/−, SPF-C57BL/6 J; Fig. S3A-C, respectively) compared to microbiota-depleted (Abx-Rag1−/−, Abx-C57BL/6 J) or gnotobiotic (GF-Rag1−/−), confirming the inverse relationship between PDAC xenograft progression and anti-tumor NK cell infiltration. This evidence concerns the gene RAG1 and neoplasm.