This activation was also confirmed by histological analysis of our MBM mouse models of human and murine melanoma bearing different BRAF mutations (intracardially inoculated mCherry-labeled WM115 [BRAF V600D], D4M.3A [BRAF V600E], or 131/4-5B1 [BRAF V600D] melanoma cells) (Supplemental Figure 1A). The gene discussed is BRAF; the disease is melanoma.