Furthermore, to understand the clinical relevance of targeting CCR2 and CCR4 receptors expressed in MBM and support our results in matched samples of MBM and PM from human patients, we plotted the expression levels of CCR2 and CCR4 collected from Cancer Cell Line Encyclopedia/DepMap (CCLE/DepMap) data sets of melanoma cell lines from the Broad Institute, where skin cutaneous melanoma (SKCM) human biopsies were derived from primary or brain metastatic sites (38). This evidence concerns the gene CCR2 and melanoma.