In oligodendrocytes, one gene, HSP90AB1, showed a male-specific significant changes with different directionality in the Tg2576 model and in human AD (male-specific decreased expression in the Tg2676 model, and male-specific increased expression in human AD), and another gene, myelin basic protein (MBP), displayed a shared male-specific under-expression in both the Tg2576 model and the human AD data (see Suppl. This evidence concerns the gene MBP and Alzheimer disease.