Among the gender-neutral DEGs in astrocytes, NRXN1 (Neurexin 1) encodes a receptor that binds neuroligins to form Ca(2 +)-dependent neurexin/neuroligin complexes at synapses in the central nervous system, a process affected by synaptic damage in AD [118]. The gene discussed is NRXN1; the disease is Alzheimer disease.