While an scRNA-seq dataset for human AD patients and controls provided too small cell counts per condition, gender and cell types for a comprehensive comparison with the Tg2576 data, in a first analysis of overlapping DEGs we identified two shared gender-neutral DEGs in astrocytes, NRXN1 and SLC1A2, and two shared male-specific DEGs in oligodendrocytes (one with consistent decreased expression, MBP, and one with opposite directionality in the Tg2576 model and in human AD, HSP90AB1, see Suppl. The gene discussed is NRXN1; the disease is Alzheimer disease.