Apart from the Klf family genes and Egr1, other transcription factors showed the ability to revert smaller subsets of downstream expression changes in the regulatory network, and have previously also been implicated in AD, including the chaperone-encoding Hsbp1 [66–69], the NF-κB Inhibitor Alpha encoding gene Nfkbia [70–72], the transcription factor Hes1 [73–75], and the vasoconstrictor endothelin-encoding Edn1 [76–78] (see Table 4). This evidence concerns the gene HES1 and Alzheimer disease.