Namely, whereas CA9 immunolabeling was found in 6 of 25 (24%) TFE3-rearranged renal cell carcinomas with a 5% threshold, in 2 of them (8%) and none of them (0%), respectively, referring to a 10% and 20% cutoff, all the TFEB-rearranged renal cell carcinomas were negative for such marker. This evidence concerns the gene TFEB and hereditary clear cell renal cell carcinoma.