While the expression is lower for TFE3-rearranged renal cell carcinomas (41%, 33%, and 29% respectively with a 5%, a 10%, and 20% threshold), most of TFEB-rearranged renal cell carcinomas labeled positive for CK8-18 (100%, 80%, and 60% respectively with 5%, 10%, and 20% threshold). The gene discussed is TFEB; the disease is hereditary clear cell renal cell carcinoma.