However, as TFE3-rearranged renal cell carcinoma, other gene fusion partners have been recently detected (COL21A1, CADM2, KHDRBS2, ACTB, EWSR1, CTLC, and NEAT1) [16–20], as well as tumors harboring TFEB gene amplification despite translocation [21–28]. Here, TFE3 is linked to hereditary clear cell renal cell carcinoma.