Speaking of TFE3-rearranged renal cell carcinomas, regardless the cutoff, a negative expression of only CK7 (p = 0.0001) and CD13 (p = 0.0018 with a 5% cutoff, p = 0.0002 with a 10% cutoff and p = 0.0001 with a 20% one) was of statistically significant value, as well as positive immunolabeling for CD10 (p = 0.0002), parvalbumin (p = 0.0016), and cathepsin K (p = 0.0001). This evidence concerns the gene CTSK and hereditary clear cell renal cell carcinoma.