For instance, in the differential diagnosis between papillary renal cell carcinoma and TFE3-rearranged renal cell carcinoma, AMACR results are statistically significant when used 20% of positivity as a threshold whereas its expression is not significant with lower cutoffs, supporting the hypothesis that it is better to consider a lower percentage of positivity. This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.