A statistically relevant correlation was also noted between TFEB-rearranged renal cell carcinomas and negativity for CK7 (p = 0.0001), AMACR (p = 0.0001), and CD13 (p = 0.0003 with a 5% threshold and p = 0.0001 with both a 10% and a 20% threshold) along with their positive expression of cathepsin K (p = 0.0001), no matter what cutoff value was considered. The gene discussed is CTSK; the disease is hereditary clear cell renal cell carcinoma.