As for TFE3-rearranged renal cell carcinomas, among 23 tumors, CD10 stained positive in 22 of the cases (96%), regardless of the cutoff considered, whereas it was positive just in 4 (40%), 3 (30%), and none (0%) of all the ten cases of TFEB-rearranged renal cell carcinomas, respectively, using a 5%, 10%, and 20% positivity threshold. The gene discussed is TFEB; the disease is hereditary clear cell renal cell carcinoma.