In cases with histological features recalling that of chromophobe carcinomas, negative expression of CK7 (p = 0.0001) and parvalbumin (p = 0.0001), along with immunolabeling for CD10 (p = 0.0001), AMACR (p = 0.0001), S100A1 (p = 0.0001), CD13 (p = 0.0001 with a 5% threshold and p = 0.0008 with both a 10% and 20% threshold), and cathepsin K (p = 0.0001) were statistically consistent with the diagnosis of MiT family translocation renal cell carcinomas, all these results observed concerning each of the above-mentioned positivity cutoffs. This evidence concerns the gene CTSK and chromophobe renal cell carcinoma.