Finally, as far as TFEB-rearranged renal cell carcinomas were concerned, negativity for CK7 (p = 0.0159 with both a 5% and 10% cutoff and p = 0.0014 with a 20% one) and parvalbumin (p = 0.0183 with a 5% threshold and p = 0.0001 with both a 10% and 20% one) as well as positive expression of S100A1 (p = 0.0001) and cathepsin K (p = 0.0001) statistically correlated with the diagnosis of such tumor subtype, despite the cutoff chosen. Here, TFEB is linked to hereditary clear cell renal cell carcinoma.