TFE3-rearranged renal cell carcinoma, as the name indicates, harbors TFE3 gene translocation which fuses with one of several other genes, such as ASPL (ASPSCR1), PRCC, SFPQ, CLTC, PARP14, RBM10, NONO, and MED15 [3–11]. This evidence concerns the gene TFE3 and renal cell carcinoma.