The analysis from TFE3-rearranged renal cell carcinomas data revealed similar results, whereas, regarding TFEB-rearranged renal cell carcinomas, cathepsin K positive staining was the only immunohistochemical result of statistical significance for all the positivity thresholds considered (p = 0.0001) and a statistical correlation was also collected with parvalbumin negativity (p = 0.0001), even though only with a 5% and 10% positivity threshold. This evidence concerns the gene CTSK and hereditary clear cell renal cell carcinoma.