BC intrinsic subtype (Luminal A, Luminal B/Her2-positive, Her2-negative, Her2-enriched, and Triple-negative subtype), tumor characteristics (e.g., tumor size, nodal status), patient characteristics (e.g., age, menopausal status), and particularly response to treatment are important parameters in estimating patient prognosis [2, 3]. The gene discussed is ERBB2; the disease is breast cancer.