Many of the top upstream regulators of invasive fibroblasts, including ERBB2 (Oh and Bang, 2020), EGFR (Robichaux et al., 2021), TNF (Wajant et al., 2003), TP63 (Melino, 2011), TP53 (Powell et al., 2014), and SMARCA4 (Concepcion et al., 2021), have been shown to be involved in tumor metastasis (Fig. 5, A and B). This evidence concerns the gene EGFR and neoplasm.