Patients with gain-of-function mutations in STIM1 and ORAI1 may also present with a rare, severe multisystem disorder, Stormorken syndrome, that shares with TAM the skeletal muscle involvement but, in line with the wide cell and tissue expression patterns of ORAI1 and STIM1, is characterized by a variety of additional symptoms that affect other tissues. This evidence concerns the gene ORAI1 and Stormorken-Sjaastad-Langslet syndrome.