RYR1 and multiminicore myopathy: A second mouse model carrying a frameshift mutation (Q1970fsX16) together with the missense mutation A4329D (RyrQ1970fsX16/A4329D) shows the main features of MmD-affected patients, with a reduction in muscle force and Ca2+ transients, associated with a decrease in RYR1 protein level of ∼65% (Elbaz et al., 2019).