As the data shown, the OS of breast cancer patient was significant difference when gene expression was changed in ALKBH3 (p=0.00063), ALKBH4 (p=0.013), ALKBH7 (p=0.0025), ALKBH8 (p=0.00013) and FTO (p=0.045) (Figure 6A). The gene discussed is ALKBH4; the disease is breast cancer.