One novel and compelling explanation for elevated anti‐inflammatory cytokines in type 2 diabetes is the development of “cytokine resistance” in which anti‐inflammatory mediators such as IL10 and IL4 lose the ability to inhibit pro‐inflammatory cytokine synthesis and secretion due to disrupted signaling in a state of chronic inflammation and insulin resistance (Barry et al., 2016; O'Connor et al., 2007). The gene discussed is INS; the disease is type 2 diabetes mellitus.