Circulating levels of TXB2, the stable metabolite of thromboxane A2, is greater in insulin resistant individuals with obesity, as well as type 1 and 2 diabetes, and has been shown to cause whole body insulin resistance, as well as adipose tissue fibrosis in rodents (Graziani et al., 2011; Lei et al., 2015; Pulcinelli et al., 2009). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.