WRAP53 and thyroid tumor: Five genes encoding telomerase holoenzyme complex main components: TERT, TERC, and accessory proteins: DKC1, TCAB1 and NAT10, showed significant differential expression between primary thyroid tumours with excellent response after initial treatment (n = 58) and clinically aggressive tumours (n = 48) (34 primary and 14 metastases) (two‐tailed Mann–Whitney U‐test p‐value < .05) (Figure 1A).