TERC and neoplasm: In differentiated tumours, telomere shortening was significantly associated with the presence of TERT promoter mutations and/or methylation (Figure 3C) with the statistical analysis being adjusted for age at diagnosis (OR = 1.57; 95%CI = 1.10–2.25; p = .013), and it correlated with the expression of TERC (Pearson r = .335, p = .0131) and DKC1, although not significant for the latest (Pearson r = .200, p = .0965) (Figure S5C).