Moreover, hsa_circ_0063425, which sponges miR-19a-3p, and hsa_circ_0056891, which sponges miR-1-3p, are positively related to AKT and PI3K, respectively, suggesting that these circRNAs may influence PI3K/AKT signaling to modulate the pathogenesis of T2DM (49). Here, AKT1 is linked to type 2 diabetes mellitus.