Serum hsa_circ_0054633, which is positively correlated with TNF-α and IL-17, is downregulated in the T2DM with insulin treatment group compared with that in the groups of healthy adults and T2DM patients without insulin treatment, suggesting that hsa_circ_0054633 may be a potential early indicator of the anti-inflammatory effects of insulin treatment (54). This evidence concerns the gene IL17A and type 2 diabetes mellitus.