NLRP3 and Global developmental delay: - Genetic analysis for NLRP3 gene  - Monitoring with fever episodes: inflammatory markers, s. procalcitonin, serum amyloid A, urine routine for proteinuria - Neurological assessment for developmental delay - Hearing assessment for SNHL - CAPS DAS (disease activity scoring) diary to be maintained by the family to monitor each episode - Fever diary to be maintained for recurrent fevers