Since among the several cytokines tested, only IFNγ counteracted the pro-apoptotic effect of TKIs on CML cells, the authors suggested that IFNγ might be the key soluble anti-apoptotic factor produced by activated T and NK cells, although this assumption has not been proven by neutralization experiments. The gene discussed is IFNG; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.