Using chemical inhibitors or siRNA knockdown we could demonstrate that the major alternative IFNγ pathways, i.e. PI3K, p38, ERK1/2, JNK1/2/3 and NF-κB, are not essential, while STAT1 signaling plays a significant role in the anti-apoptotic effect of IFNγ on CML cells. This evidence concerns the gene IFNG and chronic myelogenous leukemia, BCR-ABL1 positive.