Since transient reduction of STAT1 protein levels with a siRNA markedly counteracted the anti-apoptotic effect of IFNγ on imatinib-treated JURL-MK1 cells (Figure 3b), we conclude that the classical STAT1 pathway plays an important role in the anti-apoptotic effect of IFNγ on CML cells. Here, STAT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.