In RA model, some natural medicines (such as resveratrol, baicalin and α-mangiferin) antagonize the transcriptional activity of NF-κB by up-regulating the expression of SIRT1, thereby inhibiting the expression of a variety of inflammatory cytokines (such as TNF, IL-6 and IL-1β), and inhibiting the proliferation, invasion and migration of FLSs, which has a positive effect on RA. This evidence concerns the gene TNF and rheumatoid arthritis.