(64) showed that sinomenine could inhibit the LPS-induced immune response of macrophages by down-regulating the levels of inflammatory cytokines (TNF-α, IL-1β and IL-6) and blocking the activated TLR4/NF-κB signaling pathway, indicating that sinomenine had an immune regulation effect in RA, which was consistent with the former research. Here, TLR4 is linked to rheumatoid arthritis.