AKT1 and rheumatoid arthritis: showed that (93), tetrandrine can down-regulate the expression or activation of Akt/JNK, MMP-2, MMP-9, and fibrous F-actin and focal adhesion kinase FAK, reduce the expression of migration-related proteins Rac1, Cdc42 and RhoA in MH7A cells, and block the migration and invasion of RA-FLS.