(20) demonstrated that TNF-α induction could increase the production of IL-1β and MMP-3 inflammatory cytokines in RA-FLS, while resveratrol reduced the production of TNF-a-induced IL-1β and MMP-3 by inhibiting PI3K/Akt signaling pathway, thereby exerting the anti-inflammatory effect. Here, MMP3 is linked to rheumatoid arthritis.