A study (31) has shown that Curculigoside A (CA) can improve the symptoms of arthritis in adjuvant-induced arthritis (AIA) rats, which may be mediated by reducing the expressions of pro-inflammatory factors (IL-6, IL-1β, TNF-α) and PGE2, regulating the oxidation-oxidation balance, and down-regulating the NF-κB/NLRP3 pathway. Here, TNF is linked to arthritic joint disease.