(100) found that Triptolide could inhibit angiogenesis of RA, down-regulate the expression of angiogenic activation factors (TNF-α, IL-17, VEGF, VEGFR, ANG-1, ANG-2 and Tie2), and inhibit the activation of MAPK signaling pathway (phosphorylation of ERK, p38 and JNK). This evidence concerns the gene TNF and rheumatoid arthritis.