(38) demonstrated that ICA could inhibit the proliferation of RA-FLS and the secretion of inflammatory cytokines (TNF-α, IL-1β and IL-6), and promote the apoptosis of RA-FLS by up-regulating the miR-223-3p/NLRP3 signaling pathway. The gene discussed is NLRP3; the disease is rheumatoid arthritis.