α7 nicotinic acetylcholine receptors (α7nAChR) are key receptors for inhibiting inflammation in the cholinergic anti-inflammatory pathway, and there is a correlation between them and RA, while sinomenine can inhibit the expression of α7nAChR and exert anti-inflammatory and anti-arthritis effects through ERK/Egr-1 signaling pathway transduction (68, 69). Here, CHRNA7 is linked to Arthritis.