It has been reported (118–121) that ARS can inhibit the proliferation of chondrocytes and accelerate apoptosis and autophagy in RA rats, inhibit the migration and invasion of RA-FLSs and reduce the secretion of IL-1β, IL-6 and IL-8, alleviate inflammatory symptoms and prevent the destruction of cartilage and bone, which is related to the inhibition of NF-kB signaling pathway, the activation of PI3K/AKT/mTOR signaling pathway, and the phosphorylation of p90 ribosomal kinase 2 (RSK2). This evidence concerns the gene AKT1 and rheumatoid arthritis.