(126) showed that GCK could alleviate arthritis in AIA rats by inhibiting T cell activation, and the mechanism was through inhibiting T cell proliferation, CD25 expression and IL-2 production, as well as up-regulating immature T cells and Treg cells in the spleen, thus exerting immunomodulatory effects on RA model to improve arthritis. Here, GCK is linked to arthritic joint disease.