Previous study (51) has shown that baicalin has an anti-inflammatory effect in RA-FLS and inhibits IL-1β-induced proliferation of RA-FLS, which is related to its inhibition of NF-κB transcriptional activity and macrophage migration inhibitory factor (MIF)-mediated MAPK/ERK/p38 signaling pathway. This evidence concerns the gene NFKB1 and rheumatoid arthritis.