detected genomic profiling, underpinning renal cell carcinoma with sarcomatoid dedifferentiation, and identified TP53 (42.3%), VHL (34.6%), CDKN2A (26.9%), and NF2 (19.2%) as the most frequently altered genes for sRCC (12, 25). This evidence concerns the gene TP53 and hereditary clear cell renal cell carcinoma.