SERPINE1 and ischemic stroke: Concomitant with this, circulating and thrombi-NETs in AIS, mostly due to activation of plasminogen activator inhibitor-1 (PAI-1) expression, display a certain therapy-resistance against treatment with tissue-type plasminogen activator (t-PA), a thrombolytic agent targeting fibrin and used in the treatment regimen of ischemic stroke (107).