GPIIb/IIIa-kindlin-3-mediated integrin signaling has cell-type specific roles in DVT formation in mice, and kindlin-3 absence in platelets generally impaired platelet-neutrophil crosstalk resulting in abrogated NET formation, though this seems to be important only in the beginning of thrombus formation and dispensable in later stages (32). Here, FERMT3 is linked to deep vein thrombosis.