On the other hand, reduced caspase-2-mediated neuronal apoptosis (during development) resulting from RAIDD mutations in the DD domain, has been shown to cause thin lissencephaly and the intellectual disability associated with the loss of caspase-2-mediated apoptosis implies an important role in the development of human cerebral cortex (379). Here, CASP2 is linked to Lissencephaly.