Further, mice deficient in WDFY Family Member 4 (WDFY4) or Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3) exhibit defects in their ability to prime virus-specific CD8+ T cells in vivo or to induce tumor rejection, suggesting that cDC1 is the major cross-presenting DC subset in mice in vivo (26, 27). The gene discussed is BATF3; the disease is neoplasm.