The IFIH1 variant rs1990760 is associated with risk of T1D, SLE, RA, and multiple sclerosis (MS) (50) and results in an amino acid change from alanine to threonine at position 946 in the C-terminal of the interferon-induced helicase C-domain containing protein 1 (IFIH1 also known as MDA5). Here, IFIH1 is linked to systemic lupus erythematosus.