In the context of autoimmunity and inflammation, extracellular IL-33 binds to ST2 directly to promote local expansion, stability, and the conversion of CD4+Foxp3- T cells to Foxp3-expressing inducible Treg cells in non-lymphoid tissues (adipose tissue, skeletal muscle, and colon) (79–81). Here, FOXP3 is linked to Autoimmunity.