Current pharmacological studies have shown that Curcumin and Curcuma longa Extract seems to reverse some clinical symptoms of many autoimmune diseases by regulating immune inflammatory biological modules, such as inflammatory factors (such as IL-1, IL-17, IL-6, IL-12, TNF-α and IFN-γ) -mediated inflammatory signaling pathways and immune inflammatory cell activation, differentiation and immune function regulation. Here, TNF is linked to autoimmune disease.