CD4 and Huntington disease: As shown in Figures 2A, B, both CD4+ and CD8+ T cell subsets show increased levels of CD69 expression following exposure to CA (HD 3.7 ± 3; MS 5.7 ± 4.7 in CD4+ cells, and HD 4.3± 2.2; MS 10.7 ± 5.6 in CD8+ cells) and SC (HD 2.4 ± 1.7; MS 3 ± 2 in CD4+ cells, and HD 4.1 ± 2; MS 7.3 ± 3 in CD8+ and DN cells), with CA being consistently more immune-stimulating than SC both in HD and in pwMS.