It has been shown that stromal cells are capable of inducing epithelial-mesenchymal transformation, an event that is closely associated with the progression of inflammation to tumors (46).Margareta et al. demonstrated that FN1 functions in epithelial misplacement (AEM) and adenomas with early carcinoma (AEC) transformation in colon cancer (47), suggesting that FN1 plays a role in the inflammatory transformation of cells to colon cancer. This evidence concerns the gene FN1 and adenoma.