HMGB1 promotes the processing and presentation of tumor antigens and exerts immunostimulatory effects via binding to several pattern recognition receptors (PRRs) such as RAGE (advanced glycation end-products), toll-like receptor 2 (TLR2), and toll-like receptor 4 (TLR4) that are expressed inside DCs. The gene discussed is TLR4; the disease is neoplasm.