CLEC5A and pancreatic adenocarcinoma: In addition, the PanCox plot showed that based on the median and optimal PSI cutoffs, the PSI distribution of CLEC5A alternative splicing events was significantly negatively correlated with progression-free survival (PFS) in HNSC, KIRC, BRCA and positively associated with PFS in PAAD and LUAD, while negatively correlated with OS in LUSC, LUAD, HNSC and positively associated with OS in PAAD (Supplementary Figures 5C, D), indicating the existence of survival-associated CLEC5A alternative splicing events.