The APOE4+ genotype was previously shown to be linked with abnormal connectivity in brain networks of patients with AD and of clinically healthy subjects (Filippini et al., 2011; Damoiseaux et al., 2012; Reinvang et al., 2013, review; Dennis and Thompson, 2014, review; Foo et al., 2020; Henson et al., 2020; Wang et al., 2020; Pietzuch et al., 2021; Kang et al., 2022). The gene discussed is APOE; the disease is Alzheimer disease.