Since a wide array of mRNAs is regulated by FMRP, the simultaneous dysregulation of numerous proteins may contribute to the emergence of FXS (Brown et al., 2001; Miyashiro et al., 2003; Liao et al., 2008; Darnell et al., 2011; Klemmer et al., 2011). Here, FMR1 is linked to fragile X syndrome.