Recent studies have found that T cells are also involved in neuropathic pain: CD8+ T cells and endogenous IL-10 are required to resolve chemotherapy-induced neuropathic pain (Krukowski et al., 2016); educating CD8+ T cells can prevent and resolve chemotherapy-induced peripheral neuropathy in mice (Laumet et al., 2019; Singh et al., 2022). This evidence concerns the gene CD8A and Pain.