In spinal cord injury mice, STING knockout may alleviate inflammatory response (Wang et al., 2019); in spared nerve injury rats, STING inhibitor C-176 administration provides an antinociceptive effect that is reversed by injecting recombinant IL-6 (Sun et al., 2021), which indicates that STING is an essential downstream factor for chronic pain by regulating IL-6 expression. This evidence concerns the gene STING1 and injury.