Patients carrying the same ATP1A3 mutation tend to exhibit similar clinical phenotypes, including not only similar motor symptoms, but also non-motor symptoms, such as cognitive impairment, psychotic disorder, and verbal fluency impairment (Barbano et al., 2012; Oblak et al., 2014; Wilcox et al., 2015). This evidence concerns the gene ATP1A3 and Cognitive impairment.