The predominant ATP1A3 mutation locations in RDP patients were in exons 8, 14, 17, and 18 (a rate of 87.5%), the corresponding functional areas were domain transmembrane regions (T3 and T5) and the cytoplasmic region between T4 and T5, which was different from the reported common mutation regions in exon 5, 7, 8, 9, 16, 20, 21, and 22 of ATP1A3 in AHC (Rosewich et al., 2014b). The gene discussed is ATP1A3; the disease is dystonia 12.