METTL3 and cancer: For instance, SRY-box transcription factor 2 (SOX2) promotes development in colorectal cancer (CRC) by catalyzing methyl with methyltransferase-like protein 3 (METTL3) [12], whereas BCL2 interacting protein 3 (BNIP3) promotes cancer progression in breast cancer by catalyzing demethylation with FTO (fat mass and obesity-associated protein) [13].