Another study suggests that LINC00958 interplay with c-Myc as a feedback loop facilitating HNSCC development and resistance to chemo- and radiotherapy, and its upregulation is associated with poor tumor differentiation, advanced tumor stage, and shorter overall survival of patients (31) Another lncRNA related to DR is the plasmacytoma variant translocation 1 (PVT1), identified as upregulated in cisplatin-resistant cancer cell lines and tissue samples (108) and as a promoter of decreased sensitivity to cetuximab (135). The gene discussed is PVT1; the disease is head and neck squamous cell carcinoma.