SAMHD1 and colorectal cancer: As shown in Figure 2A, the expression level of SAMHD1 tended to be associated with the 5-year OS (SAMHD1-high vs. SAMHD1-low; HR = 1.82; 95% CI, [0.94–3.56]; and P = 0.073) among patients with stage II and III colorectal cancer.