TP53 and Familial prostate cancer: We then performed GSEA analysis on the differential genes and found that the genes were related to multiple disease pathways, such as ubiquitin-mediated protein hydrolysis (ES=0.6756, NP<0.001), cell cycle (ES=0.7008, NP<0.001), RNA degradation (ES=0.6931, NP<0.001), endometrial cancer (ES=0.5879, NP=0.0082), prostate cancer (ES=0.5439, NP=0.0041) and p53 signaling pathway (ES=0.5370, NP=0.0136) (Figure 7C).