A recent study found that NSUN2 promoted the progression of nasopharyngeal carcinoma by regulating immune infiltration (32), In our study, we also found that NSUN2 was closely associated with immune cell infiltration such as activated B cell, activated CD4 T cell, activated CD8 T cell, and NSUN2 expression also had a significant effect on immune checkpoint genes(CD28, CD80, CCL8, LAG3, HAVCR2), suggesting that NSUN2 may have an effect on the immune system through epigenetic modifications which could be a valid predictor of immunotherapy, but this needs to be further confirmed. This evidence concerns the gene LAG3 and nasopharyngeal carcinoma.