Increasing evidence has supported that ncRNAs participate in the glucose metabolic reprogramming of cancer by targeting metabolism-associated with genes, such as glucose transporter 1 (GLUT1), hypoxia-induced factor-1a (HIF-1a), and glycogen synthase 1 (GYS1). Some ncRNAs may also influence the chemoresistance to CRC. This evidence concerns the gene HIF1A and cancer.