CD274 and lung carcinoma: In the field of antitumor immunity, it was found that a decrease in cAMP concentration in the lactic acid environment of lung cancer cells inhibits PKA activity, leading to the activation of transcription activator PDZ-binding motif (TAZ) and the promotion of PD-L1 expression through the interaction between TAZ and transcription factor terminating extended area descriptor (TEAD) (13).