In this study, SOD1 expression was first detected in glioma tissue microassay (78 samples) which included four samples of brain normal tissues, 10 samples of glioma adjacent tissues, 12 samples of glioma grade I tissues, 12 samples of glioma grade II tissues, 22 samples of glioma grade III tissues, and 18 samples of glioma grade IV tissues (Bioaitech). Here, SOD1 is linked to central nervous system cancer.