Particularly, FBP1 showed DNA hypermethylation status in promoter regions in both KIRC and normal ones, which is even relatively higher in normal than that in KIRC (right panel of Figure 2A), implying that FBP1 depletion in renal cell carcinoma is not caused by DNA hypermethylation in promoter. This evidence concerns the gene FBP1 and hereditary clear cell renal cell carcinoma.