ADCY6 and neoplasm: In NSCLC, overexpression of miR-542-5p significantly inhibited tumor growth and angiogenesis, and its downstream target genes mostly came from cAMP signalling pathway, among which ADCY6 was an important target gene and was shown to be overexpressed in NSCLC tissues and participate in the process of miR-542-5p regulating tumor growth (32).