Soon after, DNA methylation profiling was done to identify a group of pHGGs that were epigenetically similar to five of the bithalamic gliomas from Mondal et al.; this group was mostly composed of midline gliomas and frequently carried EGFR alterations (mutations – 20/30, 67%; amplifications – 16/58, 27%) (18). Here, EGFR is linked to glioma.