Clinical trials showing lack of results (67)Inhibits growth in vitro, promising trial results (103, 104)Little single agent activity (68, 105)Unsuccessful phase II clinical trial (69)Cases show slowly progressive disease (13)Cases show slowly progressive disease (13)Activity against EGFR-amplified adult GBM (72)CNS penetrant, undergoing clinical trials (73, 74). The gene discussed is EGFR; the disease is glioblastoma.